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Histamine Blocking Allergy Support, EMIQ 30 VEGCAPS

Protocol For Life Balance

Histamine Blocking Allergy Support, EMIQ 30 VEGCAPS

$ 27.00 $ 30.00

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EMIQ 30 vegcaps

Dietary Supplement

- 40 Times Greater Absorption than Quercetin

EMIQ or Enzymatically Modified Isoquercitrin is prepared by using a natural enzyme process that attaches polysaccharides to convert quercetin into a soluble form (Alpha- Glycosyl Isoquercitrin). According to pharmacokinetic data, the absorption of EMIQ is up to 40 times greater (Cmax) and 15 times greater (AUC) than that of quercetin. A factor in the maintenance of good health.*

HOW IT WORKS: Quercetin is a dietary flavonol known for its ability to support a balanced immune system response.* Quercetin’s benefits however, appear to be limited by its generally poor bioavailability. Enzymatically Modified Isoquercitrin is a water soluble form of Quercetin with greatly enhanced bioavailability.*

According to pharmacokinetic data, its absorption is up to 40 times greater (Cmax) and reaches peak levels in the bloodstream in just 15 minutes.* Clinical studies show that Enzymatically Modified Isoquercitrin can support a balanced immune system and promote ocular comfort through temporary relief of itchy, watering eyes.*
• Seasonal Comfort*
• Temporary Relief of Itchy, Watering Eyes*
• Fast Acting*

SUGGESTED USAGE: Take 1 capsule 1 to 2 times daily, or
as directed by your healthcare practitioner.

Supplement Facts:
Serving size: 1 veg capsule

Amount per serving:
EMIQ® Complex 333 mg*
Enzymatically Modified Isoquercitrin 100 mg*

Other ingredients: Cellulose (capsule), Cellulose Powder
and Stearic Acid (vegetable source).

 

SUMMARY

Quercetin, a dietary flavonol known to be one of the most potent plant-derived antioxidants, has multiple biological actions, with anti-inflammatory, anti-thrombotic and vasodilatory benefits in pre-clinical studies.1 However, clinical trials have not consistently matched expected results based upon pre-clinical studies.

The limiting factor in quercetin’s clinical efficacy appears to be its poor bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin monoglucoside and its alpha-oligoglucosides that has been shown to have significantly greater bioavailability than other available forms. In animals, EMIQ was shown to produce a 40 fold increase in Cmax (peak plasma concentration) and an 18-fold increase in the area under the curve compared to quercetin.2 In humans, EMIQ supplementation increased plasma concentrations to a significantly greater degree than other forms,3 including aglycone and isoquercitrin, with randomized placebo-controlled trials documenting improvement in allergic symptoms.4,5 EMIQ has also shown significantly enhanced biological activity especially in animal models of allergy and neoplasia.6

EMIQ has shown significant effects in improving ocular symptoms of hay fever in doubleblind clinical studies. In one study, 20 subjects with hay fever due to Japanese cedar pollinosis took two capsules daily of 100 mg EMIQ or a placebo for 8 weeks during the pollen season.7 During the entire study period, total ocular score and ocular itching score for the EMIQ group were significantly lower than the placebo group. In another study of hay fever due to Japanese cedar pollinosis, 24 subjects took 100 mg EMIQ or a placebo for 8 weeks, starting 4 weeks prior to the onset of pollen release.8 During the entire study period, ocular symptom and medication scores for the EMIQ group was significantly lower than the placebo group. When limited to the pollen release period, ocular symptom and ocular congestion scores for the EMIQ group were significantly lower than the placebo group. Other scores for the EMIQ group, such as ocular itching scores, lacrimation scores, and ocular congestion scores, all tended to be lower.

 

CAUTIONS/INTERACTIONS: Quercetin may interact with antihypertensive medications, warfarin, and cyclosporin. Consult your healthcare practitioner before using this product if you are taking any of these medications or if you have any kidney dysfunction. Do Not Eat Freshness Packet. Keep in Bottle. Natural color variation may occur in this product.

 

REFERENCES

  1. Erdman JW Jr, Balentine D, Arab L, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007 Mar;137(3 Suppl 1):718S-737S.
  2. Makino T, Shimizu R, Kanemaru M, et al. Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Biol Pharm Bull. 2009 Dec;32(12):2034-40.
  3. Murota K, Matsuda N, Kashino Y, et al. alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans.Arch Biochem Biophys. 2010 Sep 1;501(1):91-7.
  4. Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
  5. Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
  6. Makino T, Kanemaru M, Okuyama S, et al. Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med. 2013 Mar 14.
  7. Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
  8. Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
  9. Hsiu SL, Hou YC, Wang YH, et al. Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci. 2002 Dec 6;72(3):227-35.

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